Ex Vivo Lentivirus Transduction and Immediate Transplantation of Uncultured Hepatocytes for Treating Hyperbilirubinemic Gunn Rat

Abstract

This work reports the first demonstration of long-term metabolic benefit after rapid transplantation of ex vivo lentivirally tranduced hepatocytes. Therefore, this study demonstrates the therapeutic proof-of-principle and potential of the SLIT approach for treating inherited metabolic liver diseases.