SYNTHESIS OF OPTICALLY ACTIVE <i>N</i>-[(<i>N</i>-ACETYL)-α-AMINOACYL]-β-AMINO ALCOHOLS BY HOMOGENEOUS AND HETEROGENEOUS ASYMMETRIC HYDROGENATIONS

Abstract

Abstract Asymmetric hydrogenations of N-(N-acetyldehydrophenylalanyl)-β-amino alcohol benzyl ethers were carried out by using either rhodium complexes with chiral and achiral phosphines or 10% palladium on carbon. The effects of the chiral center in the β-amino alcohol moiety on simple as well as double asymmetric induction are described.