Pharmacokinetics of the Enantiomers of Bupivacaine and Mepivacaine After Epidural Administration of the Racemates

Abstract

Measurements of the plasma concentrations of the enantiomers of bupivacaine and mepivacaine after epidural administration of the racemates demonstrated that the systemic disposition, but not the systemic absorption, of these drugs is enantioselective and supports the opinion that the use of single enantiomers, rather than racemates, is preferable.