Saccular Aneurysm Induction by Elastase Digestion of the Arterial Wall: A New Animal Model

Abstract

Arterial saccular aneurysms were induced in rabbits by topical application of elastase with an easy and efficient method. These aneurysms are histologically similar to natural aneurysms, and their arterial nature renders them more authentic than those of surgical models. This aneurysm model may serve as a foundation for further aneurysm research.