Planta Medica · 2000 · 68 citations · 0 references
PharmacyMedicinal ChemistryMicrobiologyAntimicrobial PharmacologyDrug DiscoveryMarine MicrobiologyAntibacterial AgentsAntibacterial PharmacologyBioactive Natural ProductsMarine Bioactive CompoundsMarine Drug DiscoveryMarine Natural ProductsAntimicrobial Marine CompoundsAntimicrobial Natural ProductsBioactive Compounds From Marine SpongesBioactive Marine Natural ProductsBioactivity ScreeningMarine Sponge MetabolitesMarine-derived Antimicrobial CompoundsSponges-derived Metabolites
A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 micrograms/ml or less, and eleven had MICs of 16 micrograms/ml or less. The most active compound found in this study was the sponge derived metabolite axisonitrile-3 (MIC 2 micrograms/ml).