MLL-AF4 Gene Fusions in Normal Newborns

Abstract

To the Editor: Uckun et al[1][1] have reported that bona fide in-frame fusion MLL-AF4 fusion sequences are detectable, using a sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method, in around 25% of normal fetal bone marrow and liver samples and in 1 of 6 infant bone