1,2,4‐Triazoles, VI¹⁾: Synthesis of New 1,5‐Diphenyl‐3‐<i>H</i>‐1,2,4‐triazoles Substituted with H‐, Alkyl, or Carboxyl Groups at C‐3

Abstract

Amidines obtained from benzamides and DMF- or DMA-dimethylacetal were cyclized with phenylhydrazines to 3H- or 3-methyltriazoles. 3-Ethyltriazoles were synthesized from diacylamides. Triazole-3-carboxylic acides were prepared starting from anilines. The compounds were assayed in the rat adjuvant induced arthritis model. Some compounds show significant anti-inflammatory activity.