Establishment of a Hypertrophic Scar Model by Transplanting Full-Thickness Human Skin Grafts onto the Backs of Nude Mice

Abstract

The intrinsic properties of human skin are the determinant of hypertrophic scar formation. The hypertrophic scar model can be established by transplanting human skin grafts onto nude mice, resulting in obvious, persistent hypertrophic scars that have both macroscopic and histologic properties similar to human hypertrophic scars. This model makes possible the observation of the entire process of hypertrophic scar formation. Thus it is an ideal tool for studying hypertrophic scar.