Cross‐Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling

Abstract

Going with the flow: The use of palladium catalysts bearing a carbene ligand resulted in a faster Murahashi coupling, and enabled its integration with the Br–Li exchange of ArBr with BuLi in a microreactor (see picture). This system allows the cross-coupling of two different aryl bromides within a minute without necessitating low temperatures (−78°C). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.