Concepedia

Preparation of Optically Pure Esomeprazole and Its Related Salt

S. V. N. RAJU, Koilkonda Purandhar, Padi Pratap Reddy, Ghanta Mahesh Reddy, Lekkala Amarnath Reddy, Kikkuru Srirami Reddy, Keshaboina Sreenath, K. Mukkanti, Ganji Santhi Reddy

Organic Process Research & Development · 2005 · 12 citations · 4 references

DOI

Concepts

Abstract

The magnesium salt of ( S )-isomer of omeprazole, with a trade name of Nexium, is the first proton-pump inhibitor developed as a single isomer for the treatment of acid-related diseases. A process for the preparation of the optically pure ( S )-isomer of omeprazole through transition metal complex is described.

References

4

Asymmetric Synthesis Using Nucleophilic Reagents Containing a Chiral Sulfoxide Group

Guy Solladié · Synthesis · 1981 · 371 citations

, , +7

Asymmetric synthesis of esomeprazole

Hanna K. Cotton, Thomas Elebring, Magnus Larsson et al. · Tetrahedron Asymmetry · 2000 · 252 citations

, , +7

Enantioseparation of selected chiral sulfoxides using polysaccharide-type chiral stationary phases and polar organic, polar aqueous–organic and normal-phase eluents

Bezhan Chankvetadze, Chiyo Yamamoto, Yoshio Okamoto · Journal of Chromatography A · 2001 · 165 citations

, , +14

Resolution of the enantiomers of omeprazole and some of its analogues by liquid chromatography on a trisphenylcarbamoylcellulose-based stationary phase

Per Erlandsson, Roland Isaksson, Pia Lorentzon et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1990 · 61 citations

, , +14