Synthetic Approaches to Oligodeoxyribonucleoside Phosphorodithioates Using Tervalent Phosphorus Monomers

Abstract

Abstract Two routes to the title compounds using nucleoside phosphorodiamidites or thiophosphoramidites have been explored. A suitably substituted thymidine thiophosphoramidite could be used for tetrazole catalysed solid support syntheses of oligomers (2 to 10 mers).