Neurology · 1989 · 29 citations · 0 references
Life SciencesGeneticsNeurologyDementiaGenetic EpidemiologyHuman GeneticsAlzheimer DiseaseDementia EpidemiologyDementia Risk FactorsNeurodegenerative DiseasesNeurodegenerative DisordersTwin StudiesAlzheimer Disease EpidemiologyEnvironmental Exposure FactorsEnvironmental FactorsGene-environment Correlation In Twin StudiesMonozygotic TwinsTwin DesignsTwin Pair DiscordanceTwin Registry Studies
We identified 3 pairs of monozygotic twins discordant for probable Alzheimer's disease from a twin register and found no systematic differences in potential risk factor exposures between affected and unaffected twins. Such cases predict a role for environmental factors in the etiology or clinical onset of Alzheimer's disease.