Membrane Array Characterization of 80 Chemokines, Cytokines, and Growth Factors in Open- and Closed-Eye Tears: Angiogenin and Other Defense System Constituents

Abstract

MAs are powerful tools for differential screening of tears for large numbers of trace proteins. Analysis allowed the identification of previously undetected proteins that may participate in the host defense system as well as demonstrated the profound change in tear composition associated with prolonged eye closure in a manner reflective of physiological function.