Evaluation of rhBMP-2 With an OPLA Carrier in a Canine Posterolateral (Transverse Process) Spinal Fusion Model

Abstract

Recombinant bone morphogenetic protein-2 carried by open-cell polyactic acid polymer is superior to autogenous iliac bone for producing radiographically and mechanically solid transverse process fusions in canines by 3 months. Spontaneous transverse process fusion does not occur in canines after decortication and open-cell polylactic acid polymer implantation.