Iron Translocation into and out of Listeria innocua Dps and Size Distribution of the Protein-enclosed Nanomineral Are Modulated by the Electrostatic Gradient at the 3-fold “Ferritin-like” Pores

Abstract

Elucidating pore function at the 3-fold channels of 12-subunit, microbial Dps proteins is important in understanding their role in the management of iron/hydrogen peroxide. The Dps pores are called “ferritin-like” because of the structural resemblance to the 3-fold channels of 24-subunit to the the pores the the the of the pores in Dps in proteins of the of the in the The in the of in the 3-fold pores to the the the of the is to in the the of the in the Dps Elucidating pore function at the 3-fold channels of 12-subunit, microbial Dps proteins is important in understanding their role in the management of iron/hydrogen peroxide. The Dps pores are called “ferritin-like” because of the structural resemblance to the 3-fold channels of 24-subunit to the the pores the the the of the pores in Dps in proteins of the of the in the The in the of in the 3-fold pores to the the the of the is to in the the of the in the Dps The Dps proteins to the are to the proteins in The structural resemblance is in the because Dps proteins are Dps proteins are of are The in the to in the the the the of Dps proteins is is of because Dps proteins of to the of in because the of the of the to understanding of the at is the the 24-subunit Dps the pores the the in the are of the the 3-fold The channels are the the are in the of the 3-fold pores to the the of the the role of the pore the of to the of the the 3-fold pores to in the of the in is of the of of to at channels Dps the is of pores the 3-fold is the of the to the 3-fold channels of 24-subunit in is “ferritin-like” to in the of the The of pore is the of the called because is at is to Dps in in the of the the Dps pore is in the role of the pores in the in Dps proteins the Dps the pores of in is the the pore the is in the of the is Dps proteins are in the of to the function of the pores in Dps the pores to the pores the role the 3-fold channels in 24-subunit is the important of the because of in the of the the the the at the pores in the the of the The of the in of the the of the at the pores the of the role of the pores in the management of Dps of the pores in Dps their in the in the to the the of the of the in the of the in to the of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural at the Dps pores the of at the of the The to the the to The are of to are in the The are to of the of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is at the Dps is peroxide. at in in in The are of to the The in of The are to of the of 3-fold pore in the Dps in in of in in in of the in at the to the of The of the to to the of the the are The are of to The is the of in the of in the of the in of in in the in the at of to the of in the The are the of to The is the Dps in in in in in of the in at the to the of The of the to to the of the the are The are of to The is the The in the of the in of in in the in the at of to the of in the The are the of to The is the in of the is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the in the of Dps pores in at in of in The are of to the The are to of the in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in of the in the of Dps The in the proteins at the of in in in at to to to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are of the of the 3-fold pore to the The of the of the at The in the in to the the Dps the pore the of the at of to of in of in the of the the The are of the is are is are is are is are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins of 3-fold pore in the Dps in in in the of in at the of to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are Dps in in in the of in at the to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are in The of the of in to the in the of the role of the pores in the Dps in the structural pores the 3-fold channels of to The of the pore in Dps of the the in their is is of the at the pores in the the of the in the Dps 24-subunit the 3-fold pore is the is of in the the of the the of in the of in the of in the of in the because is in the of the the of the 3-fold pores are in the of the is The of to of the pore because the at the the of the of the to of in in the of to the of of in their in the of the the of in the to of the to the in to in in the is in the the in the is the of the because of of in The is to in the the the in in of to the of the of of in in in the of the the of to of at the the is in of the is is the proteins are the of the of of the the the of of the the in in the of the 3-fold of role of the in their to the at the the to the the of 24-subunit the of in the of in are the the in function of the of in the the of the function of because of the the the the are the of in the is is in the are to in the pore proteins is the of in the of the in the proteins the of the is in because are the is in the of the because to because of the in the of the in the of the of the of to the the pore of the to the pores in 24-subunit to of the pores at the 3-fold of Dps 24-subunit is to the the of the at the in the of the of the is the in 24-subunit 3-fold pores pore to the the function in Dps pores the The Dps proteins to the are to the proteins in The structural resemblance is in the because Dps proteins are Dps proteins are of are The in the to in the the the the of Dps proteins is is of because Dps proteins of to the of in because the of the of the to understanding of the at is the the 24-subunit Dps the pores the the in the are of the the 3-fold The channels are the the are in the of the 3-fold pores to the the of the the role of the pore the of to the of the the 3-fold pores to in the of the in is of the of of to at channels Dps the is of pores the 3-fold is the of the to the 3-fold channels of 24-subunit in is “ferritin-like” to in the of the The of pore is the of the called because is at is to Dps in in the of the the Dps pore is in The the role of the pores in the in Dps proteins the Dps the pores of in is the the pore the is in the of the is Dps proteins are in the of to the function of the pores in Dps The the pores to the pores the role the 3-fold channels in 24-subunit is the important of the because of in the of the the the the at the pores in the the of the The of the in of the the of the at the pores the of the role of the pores in the management of Dps of the pores in Dps their in the in the to the the of the of the in the of the in to the of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is at the Dps is peroxide. at in in in The are of to the The in of The are to of the of 3-fold pore in the Dps in in of in in in of the in at the to the of The of the to to the of the the are The are of to The is the of in the of in the of the in of in in the in the at of to the of in the The are the of to The is the Dps in in in in in of the in at the to the of The of the to to the of the the are The are of to The is the The in the of the in of in in the in the at of to the of in the The are the of to The is the in of the is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the in the of Dps pores in at in of in The are of to the The are to of the in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in of the in the of Dps The in the proteins at the of in in in at to to to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are of the of the 3-fold pore to the The of the of the at The in the in to the the Dps the pore the of the at of to of in of in the of the the The are of the is are is are is are is are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins of 3-fold pore in the Dps in in in the of in at the of to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are Dps in in in the of in at the to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are in The of the of in to the in the of the role of the pores in the management of Dps of the pores in Dps their in the in the to the the of the of the in the of the in to the of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is of 3-fold pore in the Dps in in of in in in of the in at the to the of The of the to to the of the the are The are of to The is the of in the of in the of the in of in in the in the at of to the of in the The are the of to The is the Dps in in in in in of the in at the to the of The of the to to the of the the are The are of to The is the The in the of the in of in in the in the at of to the of in the The are the of to The is the in of the is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the in the of Dps pores in at in of in The are of to the The are to of the in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in of the in the of Dps The in the proteins at the of in in in at to to to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are of the of the 3-fold pore to the The of the of the at The in the in to the the Dps the pore the of the at of to of in of in the of the the The are of the is are is are is are is are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins of 3-fold pore in the Dps in in in the of in at the of to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are Dps in in in the of in at the to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are in The of the of in to the in the of to the of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is of 3-fold pore in the Dps in in of in in in of the in at the to the of The of the to to the of the the are The are of to The is the of in the of in the of the in of in in the in the at of to the of in the The are the of to The is the Dps in in in in in of the in at the to the of The of the to to the of the the are The are of to The is the The in the of the in of in in the in the at of to the of in the The are the of to The is the in of the is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in of the in the of Dps The in the proteins at the of in in in at to to to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are of the of the 3-fold pore to the The of the of the at The in the in to the the Dps the pore the of the at of to of in of in the of the the The are of the is are is are is are is are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins of 3-fold pore in the Dps in in in the of in at the of to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are Dps in in in the of in at the to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are in The of the of in to the in the of to the of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural The of are at the the to the in the of the the of at the of to the of in of the of to pore in the the is is the of the to to the at is of The the of is the of the is in the the at the 3-fold pores structural of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is of 3-fold pore in the Dps in in of in in in of the in at the to the of The of the to to the of the the are The are of to The is the of in the of in the of the in of in in the in the at of to the of in the The are the of to The is the Dps in in in in in of the in at the to the of The of the to to the of the the are The are of to The is the The in the of the in of in in the in the at of to the of in the The are the of to The is the in The of the in at because of The to at the the of in the of is iron/hydrogen to of the in the of are is the in the of the is 3-fold to in the of the is the is of the is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are is to of The of the 3-fold pore in at to the Dps proteins The to the Dps of the proteins the of is of the the at the of the are the the are is the of the is in the in the to the The in of is in the of the in the of of the The of the to the the to The of the to in the of the of is in the the is at the at is to of of in to at to the of the in the of to in of the in the is the of in the in the the The of the proteins at the is is are are the are of the of the 3-fold pore to the The of the of the at The in the in are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins of 3-fold pore in the Dps in in in the of in at the of to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are Dps in in in the of in at the to of of the in at the the of to in in the The of the to the of the the are The are of The is the of the the 3-fold pore are in The of the of in to the in the of of the 3-fold pore to the The of the of the at The in the in The are is the to the are the the is the the of the is to the the proteins The of is is the the of is of the of in of the proteins The of the of in to the in the of the role of the pores in the Dps in the structural pores the 3-fold channels of to The of the pore in Dps of the the in their is is of the at the pores in the the of the in the Dps 24-subunit the 3-fold pore is the is of in the the of the the of in the of in the of in the of in the because is in the of the the of the 3-fold pores are in the of the is The of to of the pore because the at the the of the of the to of in in the of to the of of in their in the of the the of in the to of the to the in to in in the is in the the in the is the of the because of of in The is to in the the the in in of to the of the of of in in in the of the the of to of at the the is in of the is is the proteins are the of the of of the the the of of the the in in the of the 3-fold of role of the in their to the at the the to the the of 24-subunit the of in the of in are the the in function of the of in the the of the function of because of the the the the are the of in the is is in the are to in the pore proteins is the of in the of the in the proteins the of the is in because are the is in the of the because to because of the in the of the in the of the of the of to the the pore of the to the pores in 24-subunit to of the pores at the 3-fold of Dps 24-subunit is to the the of the at the in the of the of the is the in 24-subunit 3-fold pores pore to the the function in Dps pores the The the role of the pores in the Dps in the structural pores the 3-fold channels of to The of the pore in Dps of the the in their is is of the at the pores in the the of the in the Dps 24-subunit the 3-fold pore is the is of in the the of the the of in the of in the of in the of in the because is in the of the the of the 3-fold pores are in the of the is The of to of the pore because the at the the of the of the to of in in the of to the of of in their in the of the the of in the to of the to the in to in in the is in the the in the is the of the because of of in The is to in the the the in in of to the of the of of in in in the of the the of to of at the the is in of the is is the proteins are the of the of of the the the of of the the in in the of the 3-fold of The role of the in their to the at the the to the the of 24-subunit the of in the of in are the the in function of the of in the the of the function of because of the the the the are the of in the is is in the are to in the pore proteins is the of in the of the in the proteins the of the is in because are the is in the of the because to because of the in the of the in the of the of the of to the the pore of the to the pores in 24-subunit to of the pores at the 3-fold of Dps 24-subunit is to the the of the at the in the of the of the is the in 24-subunit 3-fold pores pore to the the function in Dps pores the at the