Heparin-functionalized chitosan–alginate scaffolds for controlled release of growth factor

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

Avner Yayon, Michael Klagsbrun, Jeffrey D. Esko et al. · Cell · 1991 · 2.4K citations

Life Sciences, Biochemistry, Cell Biology +15

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Taly R. Spivak-Kroizman, Mark A. Lemmon, John E. Ladbury et al. · Cell · 1994 · 662 citations

Life Sciences, Biochemistry, Molecular Biology +14

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

Pnina Bashkin, Susan R. Doctrow, Michael Klagsbrun et al. · Biochemistry · 1989 · 595 citations

Life Sciences, Biochemistry, Molecular Biology +10

Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor

Shenshen Cai, Yanchun Liu, Xiao Zheng Shu et al. · Biomaterials · 2005 · 422 citations

Engineering, Bioengineering, Biomedical Engineering +16

Increased angiogenesis and blood vessel maturation in acellular collagen–heparin scaffolds containing both FGF2 and VEGF

Suzan T.M. Nillesen, Paul J. Geutjes, Ronnie G. Wismans et al. · Biomaterials · 2006 · 421 citations

Engineering, Bioengineering, Biomedical Engineering +14