Immunological and physiological changes associated with induced positive and negative mood.

TLDR

The study examined functional and phenotypic immune parameters before, during, and 20 minutes after inducing positive, negative, and neutral mood states in 14 male actors, each condition on a separate day. All mood states altered multiple immune parameters regardless of valence or arousal, except for the proliferative response to phytohemagglutinin, which rose after positive moods and fell after negative moods, and heart rate, physical activity, and cortisol further modulated most immune measures.

Abstract

Functional and phenotypic immunological parameters were examined before, at the end of, and 20 minutes after the induction of positive and negative mood states, varied for arousal level, and a neutral state. The subjects were 14 male actors who experienced each condition on a different day. Compared with a neutral condition, all mood states affected several immune parameters (e.g., natural killer cell percentage and activity and percentage of suppressor/cytotoxic T cells), regardless of the valence or arousal level of the mood induced. The only immune variable differentially sensitive to positive and negative mood states was the proliferative response to the mitogen phytohemagglutinin; the response increased after positive moods and decreased after negative moods. Analysis of covariance for repeated measures indicated that heart rate, alone or in combination with physical activity and cortisol levels, had an impact on mood effects for most of the immune parameters investigated.