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Response of a Murine Solid Tumor to<i>In Vivo</i>Combined Chemotherapy and Irradiation
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1973
Year
Tumor BiologyActinomycin DRadiation MedicineRadiation TherapyMedicinePharmacologyShoulder RegionBleomycin A2Head And Neck CancerMetronomic ChemotherapyClinical Radiation OncologyOncologyRadiation OncologyMurine Solid TumorNuclear MedicineCancer ResearchRadiologyHealth Sciences
The EMTG murine solid tumor was employed to examine the combined effect of gamma irradiation and chemotherapy. A dose of cyclophosphamide, actinomycin D, BCNU, and bleomycin A2, selected to yield a 10% survival fraction when given singly, was administered 2 hours before single graded doses of whole-body irradiation and the results compared to a radiation-only dose-response curve. Bleomycin A2 and BCNU modified the shoulder region of the curve. Actinomycin D was less than additive in the hypoxic region of the curve, while cyclophosphamide was simply additive throughout the curve, suggesting that it killed both well-oxygenated and poorly-oxygenated tumor cells in similar proportions.