Systemic Low‐Dose Doxycycline and Alendronate Administration and Serum Interleukin‐1Beta, Osteocalcin, and C‐Reactive Protein Levels in Rats

Abstract

Alendronate either alone or in combination with doxycycline provided slight inhibition on LPS-induced alveolar bone resorption. The significantly increased serum OC level observed in the combined drug treatment group suggests that combined administration of alendronate and doxycycline might increase bone remodeling and thereby inhibit the progression of alveolar bone resorption in rats.