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Ovarian Steroid Modulation of Prolactin Surges in Cervically Stimulated Ovariectomized Rats*
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1978
Year
Hormonal ContraceptiveProlactin SurgesFertilityGynecologyFemale Reproductive FunctionCervical StimulationMenstrual CycleReproductive BiologyReproductive EndocrinologyPublic HealthInfertilityNocturnal SurgePrl SecretionNeuropharmacologyNervous SystemEndocrinologyOvarian HormonePhysiologyOvarian Steroid ModulationMedicineReproductive Hormone
PRL secretion induced by cervical stimulation (CS) in the intact rat is characterized by a daily diurnal surge (1900 h) which recurs for 10 days and a daily nocturnal surge (0500 h) which lasts for 11 days. In ovariectomized (OV) rats, CS induces attenuated PRL surges which last for only 6 days. This study describes the effect of SC Silastic implants of estradiol (E2) or progesterone (P) on the magnitude and persistence of PRL surges in OV-CS rats. Placement of P at 1500 h and CS at 1900 h day 0 (D-0) resulted in nocturnal surges of PRL on D-2 which were significantly greater than those of blank-implanted rats. Diurnal surges of PRL on D-2 were equivalent in P and blank-implanted rats. Placement of E2 at 0800 h on the day before CS at 1900 h on D-0 resulted in an enhanced diurnal surge and extinction of the nocturnal surge of PRL on D-2 compared to blank-implanted rats. In the absence of CS, OV rats presented diurnal but no nocturnal surges of PRL in response to E2. When steroid implantation was delayed u...