Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant

Erik de Vries, Hongbo Guo, Meiling Dai, Peter J. M. Rottier, Frank J. M. van Kuppeveld, Cornelis A. M. de Haan

Emerging infectious diseases · 2015 · 92 citations · 10 references

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Abstract

In 2014, novel highly pathogenic avian influenza A H5N2, H5N5, H5N6, and H5N8 viruses caused outbreaks in Asia, Europe, and North America. The H5 genes of these viruses form a monophyletic group that evolved from a clade 2.3.4 H5N1 variant. This rapid emergence of new H5Nx combinations is unprecedented in the H5N1 evolutionary history.

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