Journal of the American Medical Association · 1959 · 14 citations · 5 references
MedicineDermatologyInfectious DiseasesDermatologic SurgeryDermatopathologyMedical MicrobiologyFungal InfectionsInfectious DermatosesSkin InfectionsSoft Tissue InfectionsSurgical Site InfectionWound InfectionCutaneous Opportunistic MycosesFungal Infections In Immunocompromised HostsInvasive Fungal InfectionsLocal Tissue InfiltrationSubcutaneous MycosesSubcutaneous MycosisSystemic Mycosis
Chromoblastomycosis is a fungus disease which has been recognized in most of the tropical and semitropical countries of the world. To date 27 cases have been reported in North America, predominantly from the southern portion of the United States.1With the possible exception of those cases where wide surgical excision was curative and not disabling, attempts to find a successful therapy have not been encouraging.2The first successful treatment of a case of chromoblastomycosis by local infiltration of amphotericin B has been reported.3Fourteen months of observation after this local therapy, there was still no clinical or laboratory evidence of a recurrence in the patient. This route of administration of amphotericin B was instituted because the intravenous therapeutic blood level of 40 mcg. per milliliter necessary to inhibit the growth of the causative organism far exceeds the maximum intravenous dose tolerated by human beings.4 Because of
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