Expression of VLDLR in the Retina and Evolution of Subretinal Neovascularization in the Knockout Mouse Model’s Retinal Angiomatous Proliferation

Abstract

VLDLR is expressed in the wild-type mouse retina, especially in RECs and RPE cells. The vldlr(-/-) mouse exhibits histologic and angiographic characteristics of RAP and is a reproducible animal model facilitating studies of the molecular mechanisms of RAP.