The Effects of Lentiviral Gene Therapy With Bone Morphogenetic Protein-2-Producing Bone Marrow Cells on Spinal Fusion in Rats

Abstract

The present study demonstrated that BMP-2-producing RBMCs, created through lentiviral gene transfer, induced sufficient spinal fusion. The use of lentiviral vectors that contain the cDNA for BMP-2 will be a novel and promising approach for a spinal fusion strategy.