Phenotypic and Functional Differences Between Wild-Type and CCR2−/− Dendritic Cells: Implications for Islet Transplantation

Abstract

In summary, lack of CCR2 interferes with the allostimulatory capacity of DC and promotes the generation of regulatory T cells. This is the first demonstration of a mechanistic link between targeting a specific chemokine pathway and the DC-regulatory T cell axis in alloimmunity.