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Stability of Omeprazole Solutions at Various ph Values as Determined by High-Performance Liquid Chromatography
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1995
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Pharmaceutical ScienceOmeprazole SolutionsPh-rate Profile CurveVarious Ph ValuesChemistryMedicinal ChemistryGas ChromatographyBioanalysisAnalytical ChemistryLiquid ChromatographyClinical ChemistryChromatographyBiochemistryChromatographic AnalysisPharmacologyPh 11High-performance Liquid ChromatographyMaximum StabilityNatural SciencesMedicinePharmacokineticsDrug DiscoveryDrug Analysis
A stability-indicating HPLC assay method for the quantitation of omeprazole has been developed. The developed method was used to study the effect of pH on the stability of omeprazole and to quantify the drug in capsules. The excipients present in the capsules did not interfere with the assay procedure. The pH-rate profile curve indicated that the maximum stability was at pH 11. Below pH 7.8, the decomposition was very fast. The decomposition constants have a direct relationship with the H+ concentrations of the solutions.