Pharmacokinetic Assessment of the Uptake of 16β-¹⁸F-Fluoro-5α-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET

Abstract

Our study explores the clinical potential of using (18)F-FDHT PET to estimate free AR concentration. This process involved the estimation of a net uptake parameter such as the k(trap) of model 1 that could serve as a surrogate measure of AR expression in metastatic prostate cancer. Our initial studies suggest that a simple body mass-normalized standardized uptake value correlates reasonably well to model-based k(trap) estimates, which we surmise may be proportional to AR expression. Validation studies to test this hypothesis are underway.