Cannabinoid receptor 1 mediates glucocorticoid‐induced bone loss in rats by perturbing bone mineral acquisition and marrow adipogenesis

Abstract

CB(1) mediates glucocorticoid-induced suppression of bone formation and marrow fat homeostasis. CB(1) antagonism reduces adipogenic and apoptotic reactions in bone microenvironments, thereby abrogating the deleterious effects of glucocorticoid treatment on bone integrity. Modulation of CB(1) signaling has therapeutic potential for preventing glucocorticoid-induced osteopenic disorders.