Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant

Abstract

A direct C-3 alkenylation of 2-methyl-4<italic>H</italic>-pyrido[1,2-<italic>a</italic>]pyrimidin-4-ones through palladium-catalyzed C–H activation using oxygen as the terminal oxidant has been developed.