Pancreatic Organotherapy for Diabetes, 1889–1921

Abstract

Best isolated a potent anti-diabetic substance which was first used on a human diabetic in January 1922. Controversy followed when Banting and Macleod, not Banting and Best, were awarded the 1923 Nobel Prize. Much has been written about the events in Toronto in 1921-1922l as well as about the priority disputes which followed.2