European Neurology · 2008 · 14 citations · 0 references
Life SciencesNeurologyNeuroscienceNeuroimmunologyNeuroinfectious DiseasesNeuropathologyAutoimmune DiseasesAutoimmune Neurological DisordersCentral Nervous System ImmunityCentral Nervous System InfectionsDemyelinating DiseasesMultiple SclerosisCerebrospinal Fluid AnalysisCerebrospinal Fluid DiagnosisCerebrospinal Fluid DiagnosticsCerebrospinal Fluid MarkersMeningitis DiagnosisMultiple Sclerosis ImmunopathogenesisMultiple Sclerosis ImmunopathologyMultiple Sclerosis Pathology
Simultaneous serum and CSF IgM determinations were made by electroimmunodiffusion in 5 normals and 203 patients. Absent from normal CSF, IgM was found in 56 patients (27%): (1) A blood-CSF transudation was present in 25 patients (12%). IgM seems of no diagnostic value in these cases. (2) A purely local synthesis was demonstrated in 17 patients (8%), concerning proved (bacterial, viral, parasitic) or supposed (multiple sclerosis) persistent infectious aggressions. (3) In the last 14 patients with IgM in CSF, a transudation was associated with a local synthesis of IgG (meningitis pattern). (4) A ratio IgM .10(3)/albumin above 10 seems an argument for multiple sclerosis.