Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein–dependent and –independent pathways by cyclin‐dependent kinase 4/6

Abstract

CDK-4/6 modulated the production of MMP-3 and MCP-1. MMP-3 production was regulated primarily at the mRNA level in an RB-independent manner, whereas MCP-1 production was controlled posttranscriptionally by RB. These results show that cell cycle proteins are associated with control of mediators of inflammation through multiple pathways.