In Vivo Visualization of the Effect of Polyclonal Antithymocyte Globulins on the Microcirculation after Ischemia/Reperfusion in a Primate Model

Abstract

ATGs have a favorable impact on early mechanisms of IRI. Due to reduced leukocyte adherence to the antigen-presenting endothelial cells, recognition events cannot take place in the posttransplant period of reperfusion. In addition to inhibiting acute transplant rejection, increase of posttransplant blood flow supports the use of ATGs as pretransplant induction therapy.