The Journal of Antibiotics · 2000 · 23 citations · 12 references
MedicineBiochemistryPharmacologyChemotherapyDrug DiscoveryDrug MetabolismCytotoxic ChemotherapyCytotoxicity EvaluationOomycete PathogenesisActinomycete Secondary Metabolism
New cytotoxic substances, designated BE-52440A and B, were isolated from the mycelium of Streptomyces sp. A52440. The active principles were extracted from the mycelium by methanol and purified by silica gel column chromatography. BE-52440A and B exhibited cytotoxic activity against murine and human tumor cell lines.
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Herbimycin, a new antibiotic produced by a strain of Streptomyces.
Satoshi Ōmura, YUZURU IWAI, Yōko Takahashi et al. · The Journal of Antibiotics · 1979 · 172 citations · Full text