Journal of Computer Assisted Tomography · 1980 · 1.2K citations · 0 references
MedicineNeurosciencePhysiologyDiagnostic ImagingNeurophysiologyNeuroradiologyBrain Energy MetabolismBrain ImagingCerebral Blood FlowCerebral PhysiologyFunctional NeuroimagingPositron Emission TomographyAerobic Energy MetabolismBlood FlowCerebral Blood Flow QuantificationMetabolic Brain ImagingOxygen Utilization RateRegional Brain MetabolismRegional Cerebral Blood FlowTissue Oxygen Extraction
The study presents a noninvasive method using inhaled 15O‑labeled CO₂ and O₂ with PET to quantify regional cerebral blood flow, oxygen extraction, and oxygen utilization in humans. The approach is grounded in theoretical modeling of 15O gas kinetics and practical PET acquisition protocols. In normal volunteers, the method measured regional cerebral blood flow, oxygen extraction, and utilization in gray and white matter, demonstrating feasibility for studying cerebral metabolism across various physiological states and neurological disorders.
A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man noninvasivey, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.