Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

James P. Grenert, W. Patrick Sullivan, Patrick Fadden et al. · Journal of Biological Chemistry · 1997 · 570 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Pigment Epithelium Proliferation in Retinal Detachment (Massive Periretinal Proliferation)

Robert Machemer, H. Laqua · American Journal of Ophthalmology · 1975 · 494 citations

Medicine, Ophthalmology, Surgery +15

Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML)

Giovanni Del Poeta, Adriano Venditti, Maria Ilaria Del Principe et al. · Blood · 2003 · 336 citations

Life Sciences, Hematology, Oncology +13

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

Nicola J. Mabjeesh, Dawn E. Post, Margaret Willard et al. · PubMed · 2002 · 299 citations

Medicine, Oncology, Pharmacology +13

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

Louis F. Stancato, Adam M. Silverstein, Janet Owens‐Grillo et al. · Journal of Biological Chemistry · 1997 · 201 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13