Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron‐Withdrawing Group‐Substituted Benzhydrols

Abstract

Abstract Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO 2 , or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf) 3 ] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further transformed into letrozole.