Six‐Month Ischemic Mice Show Sensorimotor and Cognitive Deficits Associated with Brain Atrophy and Axonal Disorganization

Abstract

tMCAo in mice induces sensorimotor and cognitive impairments detectable at least up to 6 months postinjury, associated with brain atrophy, and axonal and myelin damage of the external capsule. These behavioral tests and anatomical investigations may represent important tools in translational studies in cerebral ischemia.