Amplified Cytokine Response and Lung Injury by Sequential Hemorrhagic Shock and Abdominal Compartment Syndrome in a Laboratory Model of Ischemia-Reperfusion

Abstract

In this clinically relevant model, sequential insults of ischemia-reperfusion (HS and resuscitation) and ACS were associated with significantly increased portal and central venous cytokine levels and more severe lung injury than HS or ACS alone.