Influence of Phenylbutazone on Gastric Secretion of Mucus.

Abstract

This study was undertaken in an attempt to clarify the mechanism by which the therapeutic use of phenylbutazone sometimes causes gastric mucosal injury in the form of hemorrhage, erosions or frank ulcerations. Mucoid secretions from gastricantral pouches of dogs were studied before, during and after the oral administration of phenylbutazone in doses of 100 mg/kg of body weight. This drug decreased the rate of mucus secretions and the carbohydrate to protein ratio in non-dialyzable mucosubstance. The data suggest that gastric mucosal injury by phenylbutazone may be due to altered mucosal defense mechanisms.