Convenient and Regioselective Syntheses of 3,4-Disubstituted Δ3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3,4-Disubstituted Pyrroles

Abstract

Abstract 3,4-Disubstituted Δ3-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ3-pyrrolin-2-ones (4) starting from 2-tosylpyrroles regioselectively. The compounds 4 were found to be useful intermediates for the preparation of a variety of Δ3-pyrrolin-2-one derivatives. The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.