Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: contrasting effects of GLP-1

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

John Eng, Wayne Kleinman, L Singh et al. · Journal of Biological Chemistry · 1992 · 984 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara et al. · Journal of Biological Chemistry · 1994 · 919 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients

Tina Vilsbøll, Thure Krarup, Carolyn F. Deacon et al. · Diabetes · 2001 · 884 citations · Full text

Medicine, Endocrinology, Nutrition +16

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

M. Gutniak, Jens J. Holst, Bo Åhrén et al. · New England Journal of Medicine · 1992 · 875 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Rüdiger Göke, H. C. Fehmann, Thomas Linn et al. · Journal of Biological Chemistry · 1993 · 838 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17