Rabbit Notochordal Cells Modulate the Expression of Inflammatory Mediators by Human Annulus Fibrosus Cells Cocultured With Activated Macrophage-Like THP-1 Cells

Abstract

In an in vitro coculture system, rabbit notochordal cells reduced the levels of main inflammatory mediators and gene expression in the human AF during inflammation. Therefore, rabbit notochordal cells may constitute an important protective tool against symptomatic disc development.