Psychiatry and Clinical Neurosciences · 1999 · 24 citations · 6 references
MedicinePharmacologyPharmacotherapyNeuropharmacologyPsychopharmacologySleep MedicineRestless Legs SyndromeSleep DisturbanceSleep ManagementSleep PhysiologySleep-related Movement DisordersSleep-wake DisordersPeriodic Limb Movement Disorder PharmacotherapyPolysomnographic DiagnosisRestless Legs Syndrome PathophysiologyRestless Legs Syndrome PharmacotherapySleep Disorder MedicationsSleep QualitySleep Quality AssessmentSubjective Sleep Quality
In order to investigate the bedtime dose of talipexole, a D2 and alpha2 stimulant, on patients with periodic leg movement disorder (PLMD) and restless leg syndrome (RLS), we made a comparison of polysomnographic findings and subjective symptom ratings before and during 4 weeks of the treatment on five cases with RLS and PLMD. A significant decrease in both the frequencies of periodic leg movements and subjective symptom ratings and significant improvement of sleep composition were recognized during the treatment. We speculate that the combination of the agonistic action of D2 and alpha2 receptor with the drug might not only suppress PLMD and RLS but also improve sleep quality.
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Sleep Disruption in the Course of Chronic Levodopa Therapy
Paul A. Nausieda, William J. Weiner, Linda R. Kaplan et al. · Clinical Neuropharmacology · 1982 · 246 citations
Medicine, Neurology, Pharmacotherapy +10
Restless Legs Syndrome and Periodic Movements in Sleep
J. Montplaisir, Roger Godbout, Gaétan Poirier et al. · Clinical Neuropharmacology · 1986 · 138 citations
Randomized, Double-Blind, Placebo-Controlled Study of Clonidine in Restless Legs Syndrome
Mary Wagner, Arthur S. Walters, Rob Coleman et al. · SLEEP · 1996 · 128 citations · Full text