Heterotopic Ossification After Extremity Blast Amputation in a Sprague-Dawley Rat Animal Model

Abstract

We have developed a reproducible model for HO in the residual limbs of blast-amputated rats without addition of exogenous osteogenic stimulus. Hind limb amputation demonstrated a predilection for HO formation in comparison with forelimb amputation (P < 0.05).