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Ru(II)-Catalyzed Cascade Reactions in Stereocontrolled Construction of Rigid <i>as</i>-Indacene-Bridged Bis(α-amino acid) Derivatives
51
Citations
8
References
2002
Year
EngineeringOrganic ChemistryChemistryHeterocycle ChemistryRcm Cascade ReactionKey ConstructionOrganometallic CatalysisStereoselective SynthesisCross-coupling ReactionCatalysisPharmacologyAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringCascade ReactionsAlpha-amino Acidα-Amino AcidStereocontrolled ConstructionSynthetic Chemistry
The key construction in the preparation of as-indacene-bridged bis(alpha-amino acid) derivatives was effected by a Ru(II)-catalyzed RCM cascade reaction of appropriately substituted triynes. The latter were available after stepwise and stereocontrolled alkynylations of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine as chiral auxiliary. The regio- and stereochemical transformations have been verified by a single-crystal X-ray analysis.
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