Synthesis of the DNA Gyrase Inhibitor Microcin B17, a 43‐Peptide Antibiotic with Eight Aromatic Heterocycles in its Backbone

Abstract

One of the most unusual ribosomally synthesized and posttranslationally modified polypeptides, microcin B17, is a polypeptide antibiotic (see structure below). The total synthesis of this large molecule with oxazole and thiazole rings now enables structure–activity studies in a very important field of drug targeting.