Association of copper‐zinc superoxide dismutase (<i>SOD1</i>) and manganese superoxide dismutase (<i>SOD2</i>) genes with nonsyndromic myelomeningocele

Abstract

This study provides the first genetic evidence to support association of myelomeningocele with superoxide scavenging. The rare alleles of the five specific SNPs within SOD1 and SOD2 appear to confer a protective effect on the susceptibility for MM risk in the MM population tested. Further evaluation of the roles of superoxide scavenging and neural tube development is warranted.