Homozygous p53 Gene Mutation in a Radiation-induced Glioblastoma 10 Years after Treatment for an Intracranial Germ Cell Tumor: Case Report

Abstract

This is the first case in which a causative underlying genetic event has been identified in a radiation-induced glioblastoma. We infer that mutation of one p53 allele occurred at the time of radiotherapy, and the sudden appearance of the tumor 10 years later occurred after loss of the remaining wild-type allele and/or other genetic alterations, such as chromosome 10 loss and epidermal growth factor receptor gene amplification.