Concepedia

Publication | Closed Access

Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients

DOI

351

Citations

0

References

1993

Year

Mihae Yu, Mitchell M. Levy, Philip L. Smith, Sharon A. Takiguchi, Alison Miyasaki, Sally A. Myers
Critical Care Medicine

Abstract

Although there was no statistically significant difference in the control vs. treatment groups, subgroup analysis demonstrated a strong, significant difference between patients with supranormal values of oxygen transport vs. patients with normal levels of DO2. Supranormal values of DO2I, whether self-generated or as a result of treatment, resulted in a statistically significant decrease in mortality rate. This study adds to the weight of evidence that current standard of care of treating critically ill patients to normal DO2I should be reconsidered, and that maximizing to high DO2I might be a more appropriate therapeutic end-point.